Tlou Nkwe is a 26-year-old professional football player from RSA. He currently plays for Polokwane City FC, wearing the number 3 shirt. He plays primarily as a Defender. His preferred foot is Left. His current market value is estimated at 375K €.

His most recent move was a from Pretoria Callies FC to Polokwane City FC on 2023-06-30.

Throughout the South Africa Premier Soccer League 2025-2026, Tlou Nkwe featured in 14 matches, averaging 1.9 tackles, 1.9 interceptions, and 3.7 clearances per game, while blocking 0 shots per game.