He currently plays for Deportivo Cali Women, wearing the number 21 shirt. At the international level, he represents Colombia U17 Women. He plays primarily as a Midfield.

Across 1 appearances in the Colombian Liga Betplay Femenina 2026, Isabella Santa Espinosa registered 0 goals and 0 assists, while completing 0 key passes out of 0 total passes with a passing accuracy of -.