He currently plays for Angel City FC Women, wearing the number 20 shirt. At the international level, he represents USA Women. He plays primarily as a Defender.

Throughout the United States Women's National Soccer League 2025, Gisele Thompson featured in 23 matches, averaging 2.2 tackles, 0.7 interceptions, and 1.4 clearances per game, while blocking 0.2 shots per game.