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FA Cup: Southampton vs Arsenal Prediction & Winning Bets

EPL Betting Picks
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Match: FA Cup

Fixture: Southampton vs Arsenal

Local Kick-off Time: Apr 4, 2026 8.00pm

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ODDS

CategorySelectionValue
1X2112.00
1X2X6.25
1X221.25
Asian Handicap+1.5/21.98
Asian Handicap-1.5/21.88
Goals (Scored)Goals3/3.5
Goals (Scored)Over2.03
Goals (Scored)Under1.83

Prediction: Southampton +1.75 (90 minutes)

Following their relegation from the Premier League, Southampton endured a slump but have climbed back into the Championship playoff spots this season. They possess decent competitiveness as they host Premier League leaders Arsenal at home.

Arsenal recalled many international players on Monday due to various injuries, so the team will likely rely on players who skipped international duty and academy graduates for this match. The Gunners have a Champions League quarter-final tie in Lisbon on the Iberian Peninsula in midweek next.

The Asian handicap sets Arsenal at -1.75 goals. Arsenal are highly likely to win this match, yet winning by two goals away seems a tough task for them.

Comprehensive Prediction Analysis:

Southampton

Approaching five full decades since their last taste of FA Cup glory - having not hoisted the trophy aloft since their 1976 final victory over Manchester United - Southampton are the only team still flying the Championship flag high in the 2025-26 event.

The Saints are not the lowest-ranked team still in the tournament, however - that honour belongs to League One strugglers Port Vale - and Tonda Eckert's hosts have been demonstrating their top-flight credentials in league and knockout action recently.Doncaster Rovers, Leicester City and most recently Fulham have fallen to Southampton's FA Cup superiority; Ross Stewart's last-gasp penalty against the latter propelled the South Coast side into the quarters for the third time in the last six seasons.

Eckert's men have since taken 10 points from the last 12 on offer in the Championship - most recently defeating Oxford United 2-0 thanks partly to a 35-yard Shea Charles wonder strike - to put their playoff destiny in their own hands.A marvellous run of new-year form has seen Southampton go unbeaten in 14 games all told - winning 11 of them - and Arsenal's last FA Cup title defence ended at St Mary's behind closed doors in the 2020-21 third round.However, Arteta's men bested the Saints twice in the 2024-25 Premier League to help send Southampton down, including a 2-1 final-day success in which Kieran Tierney scored an emotional last Gunners goal.

Date/CompetitionHomeScoreAway
2026/03/21 EFL ChampionshipSouthampton2-0 (HT 2-0 FT 2-0)Oxford United
2026/03/19 EFL ChampionshipSouthampton1-0 (HT 1-0 FT 1-0)Norwich City
2026/03/14 EFL ChampionshipCoventry City1-2 (HT 0-0 FT 1-2)Southampton
2026/03/12 EFL ChampionshipWest Bromwich Albion1-1 (HT 1-0 FT 1-1)Southampton
2026/03/08 FA CupFulham0-1 (HT 0-0 FT 0-1)Southampton
2026/02/28 EFL ChampionshipSheffield Wednesday1-3 (HT 0-2 FT 1-3)Southampton
2026/02/25 EFL ChampionshipSouthampton5-0 (HT 2-0 FT 5-0)Queens Park Rangers
2026/02/21 EFL ChampionshipSouthampton1-1 (HT 0-0 FT 1-1)Charlton Athletic
2026/02/14 FA CupSouthampton2-1 (HT 1-0 FT 1-1)Leicester City
2026/02/11 EFL ChampionshipLeicester City3-4 (HT 3-0 FT 3-4)Southampton

Arsenal

The English football quadruple remains an elusive achievement for all clubs in the land, as Arsenal's dream of winning an unrivalled four trophies in one season unravelled under the Wembley arch, where Manchester City deservedly reclaimed their prized EFL Cup crown.

An Eberechi Eze and Martin Odegaard-less Arsenal had no answer to Nico O'Reilly's quickfire second-half double, in what was arguably the most alarming display of bluntness from Mikel Arteta's troops yet, as Arsenal's agonising wait for a first EFL Cup crown since 1993 continued.Nevertheless, a tremendous treble is very much within reach for the Gunners approaching the home straight, as they remain nine points clear at the Premier League summit, have a winnable Champions League quarter-final with Sporting Lisbon to look ahead to, and are just 90 minutes away from another Wembley appearance in the FA Cup.

Arsenal's 2-1 success at Mansfield in round five was very much a case of job done for Arteta's men, who have reached the quarter-finals for the first time since their last cup triumph in 2019-20; in fact, they have gone on to win the tournament on each of the last four occasions that they have reached the semi-finals.The Gunners last fell at this point to Watford in the 2015-16 campaign, and a repeat one decade later would taste especially sweet for rival supporters, who have not taken kindly to Arteta's men dropping like flies during the international break.

Date/CompetitionHomeScoreAway
2026/03/23 EFL CupArsenal0-2 (HT 0-0 FT 0-2)Manchester City
2026/03/18 UEFA Champions LeagueArsenal2-0 (HT 1-0 FT 2-0)Bayer 04 Leverkusen
2026/03/15 Premier LeagueArsenal2-0 (HT 0-0 FT 2-0)Everton
2026/03/12 UEFA Champions LeagueBayer 04 Leverkusen1-1 (HT 0-0 FT 1-1)Arsenal
2026/03/07 FA CupMansfield Town1-2 (HT 0-1 FT 1-2)Arsenal
2026/03/05 Premier LeagueBrighton&Hove Albion0-1 (HT 0-1 FT 0-1)Arsenal
2026/03/02 Premier LeagueArsenal2-1 (HT 1-1 FT 2-1)Chelsea
2026/02/23 Premier LeagueTottenham Hotspur1-4 (HT 1-1 FT 1-4)Arsenal
2026/02/19 Premier LeagueWolverhampton Wanderers2-2 (HT 0-1 FT 2-2)Arsenal
2026/02/16 FA CupArsenal4-0 (HT 4-0 FT 4-0)Wigan Athletic

Final Prediction:

Asian Handicap: Southampton +1.75 (90 minutes)

European Handicap: Arsenal Win (90 minutes)

Predicted Scores: 0-1, 1-2

Predicted Total Goals: 1, 2, 3

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